ALS Finding a Cure Request for Proposals To Develop and Validate ALS Organoid Models Overview: Organoids are a powerful new and compelling technology for studying disease biology. Several different and complementary organoid models currently exist with relevance to ALS, but none of these models has been tested across multiple ALS iPSC lines, and all have been created using different lines/genetic backgrounds making comparisons between/among them challenging. The reagents and assays used to assess ALS phenotypes have likewise varied. This variability and limited scale make it challenging to interpret results and to establish methodologic robustness. This targeted RFP aims to [...]