Accelerating identification of cross-species suppressor genes and elucidating early pathophysiology in ALS

Research Summary

Generate animal models and human cell models that will more accurately parallel familial ALS (fALS).  The team will harness strengths of four powerful model systems (worms, flies, mice, human iPSCs) to develop a robust understanding of what goes awry in ALS neurons, while also identifying conserved, cross-species suppressor genes whose perturbation could stop ALS.