Accelerating identification of cross-species suppressor genes and elucidating early pathophysiology in ALS
Generate animal models and human cell models that will more accurately parallel familial ALS (fALS). The team will harness strengths of four powerful model systems (worms, flies, mice, human iPSCs) to develop a robust understanding of what goes awry in ALS neurons, while also identifying conserved, cross-species suppressor genes whose perturbation could stop ALS.
Massachusetts General Hospital
University of Massachusetts Medical School
Robert Brown D.Phil., MD