ALS Finding a Cure® funded Eledon’s early clinical work for Tegoprubart when the drug was still with ALS TDI

2022-06-15T18:44:42+00:00

IRVINE, Calif., May 31, 2022 (GLOBE NEWSWIRE) -- Eledon Pharmaceuticals, Inc. (“Eledon”) (Nasdaq: ELDN), a patient-focused clinical stage biopharmaceutical company committed to the development of innovative and impactful treatments for organ and cell transplantation, autoimmune conditions, and neurodegenerative disease, today announced topline results from a Phase 2a clinical trial of tegoprubart (formerly AT-1501) in patients with amyotrophic lateral sclerosis (ALS).1

ALS Finding a Cure® funded Eledon’s early clinical work for Tegoprubart when the drug was still with ALS TDI2022-06-15T18:44:42+00:00

ALS Association Supports Study of SARM1 Variants

2022-04-19T13:26:30+00:00

The ALS Association, in collaboration with ALS Finding a Cure, recently awarded $400,000 to support research into the role SARM1 gene mutations play in the development and progression of ALS, with the ultimate goal of using an improved understanding of SARM1 to develop new treatments. The research will be led by Dr. Jemeen Sreedharan at King’s College London and Dr. Michael Coleman at Cambridge University.

ALS Association Supports Study of SARM1 Variants2022-04-19T13:26:30+00:00

Motor neuron toxin associated with ALS identified by UMass Chan investigators

2022-04-06T14:45:26+00:00

Motor neuron toxin associated with ALS identified by UMass Chan investigators An international team of investigators has discovered that an inorganic polyphosphate released by nerve cells known as astrocytes in people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) contributes to the motor neuron death that is the signature of these diseases. The research, by Brigitte van Zundert, PhD, adjunct professor of neurology at UMass Chan and professor at the Universidad Andres Bello in Chile; Robert H. Brown Jr., DPhil, MD, professor of neurology, and colleagues appears this week in Neuron.

Motor neuron toxin associated with ALS identified by UMass Chan investigators2022-04-06T14:45:26+00:00

Cedars-Sinai receives $11.99 million from CIRM to launch ALS clinical trial

2022-04-06T14:36:37+00:00

Cedars-Sinai receives $11.99 million from CIRM to launch ALS clinical trial Cedars-Sinai has been awarded $11.99 million by California's stem cell agency to launch a clinical trial testing a potential gene and stem cell therapy for amyotrophic lateral sclerosis (ALS). ALS, or Lou Gehrig's disease, is a progressive neurodegenerative disease that damages nerve cells known as motor neurons in the brain and spinal cord that control voluntary muscle movement. It affects an estimated 16,000 people in the U.S. and is usually fatal within five years of diagnosis. There is no known cure and only limited treatments that may slow progression [...]

Cedars-Sinai receives $11.99 million from CIRM to launch ALS clinical trial2022-04-06T14:36:37+00:00

Healey Center for ALS in partnership with ALS Finding a Cure announces the 2021 ALS Scholars in Therapeutics Recipients

2022-04-06T14:10:45+00:00

Class of 2021 The Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH) in partnership with ALS Finding a Cure (ALSFAC) selected four recipients for their inaugural global two-year ALS Scholars in Therapeutics program. The program received an outstanding pool of global applications from 6 countries. This year’s selected recipients are Juliet Goldsmith, PhD of University of Pennsylvania, Matthew Anthony White, PhD of Kings College London, Brian Jude Joseph, PhD of Harvard University and Su Min Lim, PhD of Massachusetts General Hospital, Harvard Medical School. Learn about the ALS Scholars Program. [...]

Healey Center for ALS in partnership with ALS Finding a Cure announces the 2021 ALS Scholars in Therapeutics Recipients2022-04-06T14:10:45+00:00

ALSFAC-Funded Project Announces Successful ALS Clinical Trial and High-Profile Publication

2021-09-07T16:20:37+00:00

ALSFAC-Funded Project Announces Successful ALS Clinical Trial and High-Profile Publication Amylyx, a start-up biotech company developing new treatments for ALS supported by ALS Finding a Cure®, and Mass General Hospital, announced the publication of results from its successful pivotal stage ALS clinical trial in the prestigious New England Journal of Medicine (NEJM). ALS Finding A Cure® provided two grants to Amylyx: the first in collaboration with Cure Alzheimer’s Disease to support required preclinical toxicology studies, and the second to fund this trial in collaboration with The ALS Association as part of the ALS ACT initiative.  The clinical trial, known as [...]

ALSFAC-Funded Project Announces Successful ALS Clinical Trial and High-Profile Publication2021-09-07T16:20:37+00:00

ALSFAC Funded Research Turns Off Key Gene in Families with ALS

2021-09-07T16:20:37+00:00

ALSFAC Funded Research Turns Off Key Gene in Families with ALS Researchers at the University of Massachusetts Medical School and Massachusetts General Hospital report progress on a potential new weapon against the fatal nerve disease ALS. Read More Report Progress

ALSFAC Funded Research Turns Off Key Gene in Families with ALS2021-09-07T16:20:37+00:00

Team of Five Labs Launches Novel Attack on ALS

2021-09-07T16:20:37+00:00

Team of Five Labs Launches Novel Attack on ALS Amyotrophic Lateral Sclerosis (ALS) can arise from aberrant genes. A group of five Brown University professors proposes that a cure may also come from aberrant genes – genetic mutations that suppress ALS. A new research grant supports their comprehensive investigation of ALS in flies, worms, mice and human cells.

Team of Five Labs Launches Novel Attack on ALS2021-09-07T16:20:37+00:00

Progress Coming in Amyotrophic Lateral Sclerosis, but Rigorous Studies Needed

2021-09-07T16:20:37+00:00

Progress Coming in Amyotrophic Lateral Sclerosis, but Rigorous Studies Needed The community of individuals living with amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, has endured many false hopes for promising therapies and is still waiting for the first disease-modifying drug. Nevertheless, "we have made huge progress in the last decade in ALS," Merit Cudkowicz, professor of neurology at Harvard Medical School and chief of the neurology service and director of the MDA ALS clinic at Massachusetts General Hospital, told participants in an integrated neuroscience session on ALS at the American Academy of Neurology... READ MORE [...]

Progress Coming in Amyotrophic Lateral Sclerosis, but Rigorous Studies Needed2021-09-07T16:20:37+00:00

Johns Hopkins University, Cedars-Sinai and Massachusetts General Hospital Announce Groundbreaking ALS Research Project of Answer ALS

2022-03-09T16:33:09+00:00

Johns Hopkins University, Cedars-Sinai and Massachusetts General Hospital Announce Groundbreaking ALS Research Project of Answer ALS Research Designed to Fully Understand and Defeat ALS; “Big Data” Technology Will Drive Unprecedented Analysis Capability $20 Million in Funding from Committed Team of Donors, including the National Football League, the PGA TOUR, ALS Finding a Cure (a project of the Leandro P. Rizzuto Foundation), Travelers, The Fishman Family and The Bari Lipp Foundation BALTIMORE, LOS ANGELES and BOSTON, September 9, 2015 – Johns Hopkins University’s Robert Packard Center for ALS Research, Cedars-Sinai Medical Center’s Regenerative Medicine Institute and the Massachusetts General Hospital Neurological [...]

Johns Hopkins University, Cedars-Sinai and Massachusetts General Hospital Announce Groundbreaking ALS Research Project of Answer ALS2022-03-09T16:33:09+00:00
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